• Coenzyme Q10 for Various Ailments Treatment
  • Coenzyme Q10 is not approved by the US Food and Drug Administration (FDA) for the treatment of any medical condition. It is sold as a dietary supplement. In the US supplements are not regulated as drugs but as foods. How CoQ10 is manufactured is not regulated and different batches and brands may vary significantly.

    Coenzyme Q10 is generally well tolerated. The most common side effects are gastrointestinal symptoms (nausea, vomiting, appetite suppression and stomachache), rash and headache.
     

    coenzyme Q10
    Coenzyme Q10
     

    Heart failure

    A 2014 Cochrane Collaboration meta-analysis found "no convincing evidence to support or refute" the use of CoQ10 for the treatment of heart failure. The analysis identified seven studies that met criteria but identified problems with possible bias, applicability to the general population and failure to identify clinically meaningful outcomes in these studies. The authors concluded, "Until further evidence emerges to support the use of coenzyme Q10 in heart failure, there might be a need to re-evaluate whether further trials testing coenzyme Q10 in heart failure are desirable."

    Huntington disease

    Available evidence suggests that "Coenzyme Q10 is likely ineffective in moderately improving" Huntington disease chorea.

    Male infertility

    While CoQ10 can improve some measurements regarding sperm quality, there is no evidence that CoQ10 increases live births or pregnancy rates.

    Migraine headaches

    Supplementation of CoQ10 has been found to have a beneficial effect on the condition of some sufferers of migraine. This is based on the theory that migraines are a mitochondrial disorder, and that mitochondrial dysfunction can be improved with coenzyme Q10. The Canadian Headache Society guideline for migraine prophylaxis recommends, based on low-quality evidence, that 300 mg of CoQ10 be offered as a choice for prophylaxis.

    Statin myopathy

    CoQ10 has been routinely used to treat muscle breakdown associated as a side effect of use of statin medications. However, there is little rigorous evidence from clinical trials supporting its use for this purpose.

    Cancer

    No large well-designed clinical trials of CoQ10 in cancer treatment have been done. The National Cancer Institute identified issues with the few, small studies that have been done stating, "the way the studies were done and the amount of information reported made it unclear if benefits were caused by the CoQ10 or by something else". The American Cancer Society has concluded, "CoQ10 may reduce the effectiveness of chemo and radiation therapy, so most oncologists would recommend avoiding it during cancer treatment."

    Blood pressure

    A 2009 Cochrane review concluded that studies looking at the effects of coenzyme Q10 on blood pressure were unreliable, and therefore no conclusions could be made regarding its effectiveness in lower blood pressure.

    Periodontal disease

    A review study has shown that there is no clinical benefit to the use of CoQ10 in the treatment of periodontal disease. Most of the studies suggesting otherwise were outdated, focused on in-vitro tests, had too few test subjects and/or erroneous statistical methodology and trial set-up, or were sponsored by a manufacturer of the product.

    Parkinson's disease

    A 2011 review by the Cochrane Collaboration suggesting coenzyme Q10 supplementation might benefit people with Parkinson's diseasewas subsequently withdrawn from publication following a review by independent editors.
     

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