• More Information about Yohimbine
  • Yohimbine is an ingredient with stimulant and aphrodisiac effects. It is sold as prescription medicine for the treatment of sexual dysfunction.

    Yohimbine is an alkaloid naturally found, along with several other active alkaloids, in Pausinystalia yohimbe (Yohimbe), Rauwolfia serpentina (Indian Snakeroot), and Alchornea floribunda (Niando). Yohimbine has been used as an over-the-counter dietary supplement in herbal extract form.

    The therapeutic index of yohimbine is quite low. the range between an effective dose and a dangerous dose is very narrow. A typical dose for sexual dysfunction would be 15–30 mg, whereas 100 mg would be considered dangerous. Yohimbine should not be consumed by anyone with liver, kidney, heart disease, or a psychological disorder.

    Yohimbe bark is on the FDA list of dangerous supplements. The levels of yohimbine that are present in yohimbe bark extract are variable and often very low. However, it is important to note that while the terms yohimbine, yohimbine hydrochloride, and yohimbe bark extract are related, they are not interchangeable.

    Yohimbe bark extract

    In addition to the main active chemical, yohimbine, Pausinystalia yohimbe contains approximately 55 other alkaloids, of which yohimbine accounts for 1% to 20% of total alkaloids. Hence the use of yohimbe bark extract in sufficient dosages may provide concomitant α1 and α2 receptors blockade and thus may better enhance erections than yohimbine alone.

    Pausinystalia yohimbe is currently threatened with extinction in its native habitat due to international demand. Its conservation is difficult because the bioactivity of the tree has led many Western governments to declare it a proscribed species.

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