• The Study of Soy Isoflavone in Soybean Extract
  • Soy isoflavone distillate or concentrate is extracted from the seeds or beans of the soy herb. Soybean encloses several elements or compounds such as isoflavones and lecithin that are therapeutically very valuable.

    Isoflavones are a class of phytoestrogens—plant-derived compounds with estrogenic activity. Soybeans and soy products are the richest sources of isoflavones in the human diet. (More Information)

    The results of randomized controlled trials suggest that substituting 50 g/day of soy protein for animal protein results in only a modest 3% reduction of LDL cholesterol. Isolated soy isoflavone supplements do not appear to have favorable effects on serum lipid profiles. (More Information)

    Consumption of soy isoflavones, at doses of <90 mg/day, may inhibit bone resorption and stimulate bone formation (More Information)

    Overall, the results of numerous observational studies do not support the idea that high soy isoflavone intakes in adults are protective against breast cancer. Limited research suggests that higher intakes of soy foods early in life may decrease the risk of breast cancer in adulthood. (More Information)

    Although scientists are interested in the potential for soy isoflavones to prevent or inhibit the progression of prostate cancer, evidence from observational studies that soy isoflavones are protective against prostate cancer is limited and inconsistent. (More Information)
     

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    To date, studies on the effect of soy isoflavone consumption on menopausal symptoms have reported mixed results. (More Information)

    Some health effects of soy isoflavones may be dependent on whether or not the isoflavone metabolite, equol, is produced. (More Information)

    Although diets rich in soy or soy-containing products appear safe and potentially beneficial, the long-term safety of high doses of soy isoflavone supplements is not yet known. (More Information)

    At present, there is no convincing evidence that infants fed soy-based formula are at greater risk for adverse effects than infants fed cow’s milk-based formula. (More Information)

    Soy Isoflavone Biological Activities

    Soy isoflavones are known to have weak estrogenic or hormone-like activity. Estrogens are signaling molecules that exert their effects by binding to estrogen receptors within cells (chemical structures of endogenous estrogens). The estrogen-receptor complex interacts with DNA to change the expression of estrogen-responsive genes. Estrogen receptors are present in numerous tissues other than those associated with reproduction, including bone, liver, heart, and brain . Soy isoflavones and other phytoestrogens can bind to estrogen receptors, mimicking the effects of estrogen in some tissues and antagonizing (blocking) the effects of estrogen in others . Scientists are interested in the tissue-selective activities of phytoestrogens because anti-estrogenic effects in reproductive tissue could help reduce the risk of hormone-associated cancers (breast, uterine, and prostate), while estrogenic effects in other tissues could help maintain bone density and improve blood lipid profiles (cholesterol levels). The extent to which soy isoflavones exert estrogenic and anti-estrogenic effects in humans is currently the focus of considerable scientific research.

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