• Yohimbe Bark Extract for Sexual Dysfunction
  • Yohimbe bark extract is widely used for curing sexual dysfunction that resulted from tension, pressure and fatigue. Meanwhile, it could also increase the strain of sexual muscle, which is provided with the urine repressing function with no damnification. In addition, it could speed energy circulation of body to increase the energy supply. At present, it is mainly used as the raw material of nourishi-ment in improving sexual performance. It has also shown to be effective in treating sexual dysfunction caused by psychological reasons, like stress, tension or fatigue, combats weight loss.

    Yohimbe bark extract

    Yohimbe Bark Extract for Sexual Dysfunction:

    The NIH states that yohimbine hydrochloride is the standardized form of yohimbine that is available as a prescription medicine in the United States, and that it has been shown in human studies to be effective in the treatment of male erectile dysfunction. Yohimbine has been shown to be effective in the treatment of orgasmic dysfunction in men. Yohimbine has also been used to treat hypoactive sexual desire disorder (under active libido) in women.

    Large doses of yohimbe have caused priapism. Controlled studies suggest that it is not always an effective treatment for impotence, and evidence of increased sex drive (libido) is anecdotal.

    It cannot be excluded that orally administered yohimbine can have a beneficial effect in some patients with ED. The conflicting results available may be attributed to differences in drug design, patient selection, and definitions of positive response. Generally, however, available results of treatment are not impressive.

    Yohimbine blocks the pre- and post-synaptic α2 receptors. Blockade of post-synaptic α2receptors causes minor corpus cavernosum smooth muscle relaxation. In fact, the majority of adrenoceptors in the corpus cavernosum are of the α1 type. Blockade of pre-synaptic α2receptors facilitates the release of several neurotransmitters in the central and peripheral nervous system — thus in the corpus cavernosum — such as nitric oxide and norepinephrine. Whereas nitric oxide released in the corpus cavernosum is the major vasodilator contributing to the erectile process, norepinephrine is the major vasoconstrictor through stimulation of α1 receptors on the corpus cavernosum smooth muscle. Under physiologic conditions, nitric oxide attenuates norepinephrine vasoconstriction. Continuous administration of yohimbine, as opposed to on-demand administration, might result in increased norepinephrine reuptake and thereby reduced vasoconstriction from reduced α1 adrenergic receptors stimulation by its feedback down regulation mechanism -unlike on-demand administration that produces excessive norepinephrine release and bottlenecked reuptake. And α1 blockers on-demand reduce vasoconstriction caused by excessive norepinephrine release.

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